Deubiquitination of epidermal growth factor receptor by ubiquitin-specific peptidase 54 enhances drug sensitivity to gefitinib in gefitinib-resistant non-small cell lung cancer cells.

A precise balance between ubiquitination and deubiquitination is crucial for cellular regulation.Ubiquitin-specific peptidase 54 (USP54), an active deubiquitinase (DUB), modulates the ubiquitination of the epidermal growth factor receptor (EGFR).While the significance of USP54 in tumorigenesis is known, its specific function in cancer progression r

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Resisting System: Britain, Buffon, And The Avoidance of Linnaeus

It is a commonplace of science (although less of the history of OXYCUR PLATIN LIGHTENING POWDER science) that Linnaeus definitively solved the vexing problems of taxonomy and nomenclature in the 18th century, thus freeing subsequent researchers to focus on more challenging problems.In fact the reception of the Linnaean system was slow and incomplet

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The unsolved problem of solar-wind turbulence

The solar wind forms the largest wind tunnel for plasma and magnetofluid turbulence that is accessible to Earth.It evolves from what is thought to be a turbulent source that continues to drive nonlinear turbulent dynamics as it expands outward via large-scale, energy-containing wind shear and shocks.In the outer heliosphere, once the gradients in t

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Sexual Dimorphism in the Age of Genomics: How, When, Where

In mammals, sex chromosomes start to program autosomal gene expression and epigenetic patterns very soon after fertilization.Yet whether the resulting sex differences are perpetuated throughout development and how they connect to Speed Controller the sex-specific expression patterns in adult tissues is not known.There is a dearth of information on

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